Sodium Hydroxide → HCID 23684697, 화합물

HRID 2051880노트

반응식

HRID 2051880 반응식
[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19].[OH-].[Na+:22]>O>[OH2:16].[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O-:20])=[O:19].[Na+:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 173842Ahr 6293

생성물 1

HCID 23684697HCID 23684697, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3.5 g. (0.0125 mole) of 2-amino-3-(p-chlorobenzoyl)phenylacetic acid in a water solution containing 0.5 g. of sodium hydroxide (0.125 mole) was refluxed 45 minutes, cooled and filtered. The filtrate was concentrated to an oily consistency and poured into a large volume of acetone. A yellow precipitate separated which was collected and identified by nuclear magnetic resonance spectrum as the desired product. The product (2.6 g.) (67%) melted at 265° C. (dec.) after crystallization from ethanol-ethyl ether.

후처리

  1. additionA mixture of 3.5 g
  2. temperaturecooled
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated to an oily consistency
  5. additionpoured into a large volume of acetone
  6. customA yellow precipitate separated which
  7. customwas collected
  8. customThe product (2.6 g.) (67%) melted at 265° C. (dec.) after crystallization from ethanol-ethyl ether

출처 및 근거

ORD 기록
ord-988a9446923e4e0aaac98e2a2f779d9a
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182774

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