Sodium Hydroxide → HCID 12901229, 화합물

HRID 2051882노트

반응식

HRID 2051882 반응식
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:16]=2[NH:15][C:14](=[O:17])[CH2:13]3)=[O:7])=[CH:4][CH:3]=1.[OH-:20].[Na+]>O>[NH2:15][C:16]1[C:8]([C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:9][CH:10]=[CH:11][C:12]=1[CH2:13][C:14]([OH:20])=[O:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12901224HCID 12901224, 화합물

생성물 1

HCID 12901229HCID 12901229, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1.5 g. (0.006 mole) of 7-(4-fluorobenzoyl) indolin-2-one in 50 ml. of 3 N sodium hydroxide was refluxed under nitrogen for 45 min. The solution was cooled, diluted with an equal volume of water, filtered, and the filtrate was extracted two times with 50 ml. of ether. The aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate formed. The precipitate was filtered off, washed thoroughly with water and air-dried. The yield was 1.1 g. (68%); m.p. 136°-137° C.

후처리

  1. additionA mixture of 1.5 g
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. extractionthe filtrate was extracted two times with 50 ml
  5. additionThe aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate
  6. customformed
  7. filtrationThe precipitate was filtered off
  8. washwashed thoroughly with water
  9. customair-dried

출처 및 근거

ORD 기록
ord-74cc7a58287a4d6f9a4946528038e75e
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182774

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