Hydrochloric Acid → p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

HRID 2051920노트

반응식

HRID 2051920 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=1.[OH-].[K+].Cl>C(O)C.O.O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 23468273Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate

생성물 1

HCID 23468295p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

A mixture of 3.0 g of ethyl p-{[2-(2-naphthyloxy)-ethyl]amino}benzoate, and 3.0 g of potassium hydroxide in 200 ml of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1) to give the product, mp 208°-211° C.

후처리

  1. temperatureis refluxed for 3 hours
  2. filtrationThe mixture is filtered
  3. washthe solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1)
  4. customto give the product, mp 208°-211° C.

출처 및 근거

ORD 기록
ord-f6ebdbaed33e415fbc59f1491b6d7e68
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182776

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