3-(4-Fluorophenoxy)propionic acid → 1-Propanol, 2-(4-fluorophenoxy)-

HRID 2051928노트

반응식

HRID 2051928 반응식
B#B.[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[CH2:10][OH:11])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 38721403-(4-Fluorophenoxy)propionic acidHCID 6328200Diboron

생성물 1

HCID 104647301-Propanol, 2-(4-fluorophenoxy)-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 95 ml. of diborane in 95 ml. of tetrahydrofuran was added 10.2 g. of 2-(4-fluorophenoxy)propionic acid in 100 ml. of tetrahydrofuran. The reaction mixture was stirred at room temperature for 20 hours. The solution was gradually poured onto 600 g. of ice and extracted (3×-250 ml each) with chloroform. The combined organic layer was extracted with water (3×-50 ml each) and dried. The solvent was removed under vacuum giving a clear liquid.

후처리

  1. additionThe solution was gradually poured onto 600 g
  2. extractionof ice and extracted (3×-250 ml each) with chloroform
  3. extractionThe combined organic layer was extracted with water (3×-50 ml each)
  4. customdried
  5. customThe solvent was removed under vacuum
  6. customgiving a clear liquid

출처 및 근거

ORD 기록
ord-2b65110274a9450c852a727ab72536fe
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182776

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