Hydrochloric Acid → HCID 131711700, 화합물

HRID 2052273노트

반응식

HRID 2052273 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([NH:15][C@H:16]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@@H:32]([C:39]([NH2:41])=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:25][C:26](=[O:28])[OH:27])=[O:22])[CH2:17][CH2:18][CH2:19][CH3:20])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[ClH:49].SC(O)C>O1CCOCC1>[NH2:1][C@H:2]([C:13]([NH:15][C@H:16]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@@H:32]([C:39]([NH2:41])=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:25][C:26](=[O:27])[OH:28])=[O:22])[CH2:17][CH2:18][CH2:19][CH3:20])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[ClH:49]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4713212Mercapto-ethanolHCID 131711697HCID 131711697, 화합물

생성물 1

HCID 131711700HCID 131711700, 화합물수율 99%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2.20 g (3.32 mmoles) of BOC-Trp-Nle-Asp-D-Phg-NH2 are treated with 25 ml of 4 n hydrochloric acid in dioxane in the presence of 1.20 ml (17 mmoles) of mercaptoethanol. After 15 minutes the solution is evaporated in vacuo, the residue is triturated with ether, and the solid is filtered off. 1.99 g (99.0%) of H-Trp-Nle-Asp-D-Phg-NH2.HCl are obtained; m.p.: 217°-221° C. (decomposition), Rf7 :0.35, [α]D :-54.2° (c: 1.0, in dimethyl formamide).

후처리

  1. customAfter 15 minutes the solution is evaporated in vacuo
  2. customthe residue is triturated with ether
  3. filtrationthe solid is filtered off

출처 및 근거

ORD 기록
ord-ee3ef9bcea594fca964243d3187c2396
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04183909

반응 노트

불러오는 중…