Methyl iodide → HCID 20377886, 화합물

HRID 2052419노트

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HRID 2052419 반응식
Cl.[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:19][I:20]>CC(C)=O>[CH3:19][I:20].[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 20377895(Pyridin-3-yl)methyl 4-fluorobenzoate--hydrogen chloride (1/1)

생성물 1

HCID 20377886HCID 20377886, 화합물수율 60%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
0 °C

실험 절차

4.4 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine hydrochloride prepared according to Example 1 (a) are dissolved in 40 ml. of acetone and 3 g. of methyl iodide are added thereto. The reaction mixture is refluxed for 30 minutes and then cooled to 0° C. The precipitated quaternary salt is separated by filtration and recrystallized from 100 ml. of anhydrous ethanol. 4.2 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine methyliodide (60% of theoretical yield) are obtained; m.p.: 132°-133° C.

후처리

  1. dissolutionare dissolved in 40 ml
  2. temperatureThe reaction mixture is refluxed for 30 minutes
  3. customThe precipitated quaternary salt is separated by filtration
  4. customrecrystallized from 100 ml

출처 및 근거

ORD 기록
ord-03a26ac6a7954575958f0883efb484e1
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04184040

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