Hydrochloric Acid → 4-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

HRID 2052485노트

반응식

HRID 2052485 반응식
[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Cl>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079673Ethyl 4-({[4-(benzyloxy)phenyl]methyl}amino)benzoate

생성물 1

HCID 130796724-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

A mixture of 10 g. of ethyl p-[p-(benzyloxy)benzylamino]benzoate (prepared as described in Example 11) 10 g. of potassium hydroxide and 200 ml. of ethanol-water (9:1) are refluxed for 4.5 hours. While hot, the mixture is acidified with concentrated hydrochloric acid. Dilution with water and filtration gives tan crystals which are recrystallized from glacial acetic acid to give off-white crystals, m.p. 206°-208° C.

후처리

  1. additionA mixture of 10 g
  2. filtrationDilution with water and filtration
  3. customgives tan crystals which
  4. customare recrystallized from glacial acetic acid
  5. customto give off-white crystals, m.p. 206°-208° C.

출처 및 근거

ORD 기록
ord-c8ad0d790e8f408a9a811561f269b2d0
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04185115

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