Hydrochloric Acid → 4-[(3-Phenylpropyl)amino]benzoic acid

HRID 2052494노트

반응식

HRID 2052494 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:11]2[CH:21]=[CH:20][C:14]([C:15]([O:17]CC)=[O:16])=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].C(O)C.O.Cl>O>[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:15]([OH:17])=[O:16])=[CH:20][CH:21]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079659Ethyl 4-[(3-phenylpropyl)amino]benzoateHCID 19096565Water ethanol

생성물 1

HCID 130796584-[(3-Phenylpropyl)amino]benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10 g. of ethyl p-[(3-phenylpropyl)amino]benzoate (prepared as described in Example 26), 10 g. of KOH and 200 ml. of ethanol-water (9:1) is refluxed for 4 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with water, cooled and filtered to give off-white crystals. Recrystallization from ethanol gives off-white crystals, m.p. 162°-163° C.

후처리

  1. additionA mixture of 10 g
  2. temperaturecooled
  3. filtrationfiltered
  4. customto give off-white crystals
  5. customRecrystallization from ethanol
  6. customgives off-white crystals, m.p. 162°-163° C.

출처 및 근거

ORD 기록
ord-ba8d7a0c2e884974a47cab8607644399
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04185115

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