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Hydrochloric Acid → 4-[(10-Phenyldecyl)amino]benzoic acid

HRID 2052495
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인쇄 미리보기

반응식

HRID 2052495 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]2[CH:28]=[CH:27][C:21]([C:22]([O:24]CC)=[O:23])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].C(O)C.O.Cl>O>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]2[CH:19]=[CH:20][C:21]([C:22]([OH:24])=[O:23])=[CH:27][CH:28]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079661Ethyl 4-[(10-phenyldecyl)amino]benzoateHCID 19096565Water ethanol

생성물 1

HCID 130796604-[(10-Phenyldecyl)amino]benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 7.0 g. of ethyl p-[(10-phenyldecyl)amino]benzoate (prepared as described in Example 28), 7 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with water, cooled and filtered to give white crystals, m.p. 80°-87° C. Recrystallization from ethanol gives white crystals, m.p. 96°-98° C.

후처리

  1. additionA mixture of 7.0 g
  2. temperaturecooled
  3. filtrationfiltered
  4. customto give white crystals, m.p. 80°-87° C
  5. customRecrystallization from ethanol
  6. customgives white crystals, m.p. 96°-98° C.

출처 및 근거

ORD 기록
ord-287bf72a7fc543d48cf0c095930c196f
출처 데이터셋
uspto-grants-1980_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04185115

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