Diisopropylethylamine → HCID 178448293, 화합물

HRID 2053331노트

반응식

HRID 2053331 반응식
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[NH2:20][C@H:21]([CH:24]([CH3:26])[CH3:25])[CH2:22][OH:23].CCN(C(C)C)C(C)C>>[OH:23][CH2:22][C@H:21]([NH:20][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[CH:24]([CH3:26])[CH3:25]

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 6950587D-ValinolHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

생성물 1

HCID 178448293HCID 178448293, 화합물

실험 절차

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (R)-2-amino-3-methyl-butan-1-ol and DIEA to give 2-((R)-1-hydroxymethyl-2-methyl-propylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 342 (MH+).

출처 및 근거

ORD 기록
ord-22a4f35246ca4c7c803a37e8ec7aea68
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326786B2

반응 노트

불러오는 중…