Hydrochloric Acid → 3-(3-Methyl-isoxazol-5-yl)-2-oxo-4-phenyl-1,2-dihydroquinoline-6-carboxaldehyde

HRID 2053432

반응식

HRID 2053432 반응식
C(O[C:4]([C:6]1[C:7](=[O:23])[NH:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12](Cl)=[CH:11][CH:10]=2)=[O:5])C.Cl.[O:25]1[CH2:30]COCC1>O>[CH3:14][C:9]1[CH:10]=[C:4]([C:6]2[C:7](=[O:23])[NH:8][C:9]3[C:14]([C:15]=2[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:13][C:12]([CH:30]=[O:25])=[CH:11][CH:10]=3)[O:5][N:8]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 738703Ethyl 6-chloro-2-oxo-4-phenyl-1,2-dihydro-3-quinolinecarboxylate

생성물 1

HCID 1360186723-(3-Methyl-isoxazol-5-yl)-2-oxo-4-phenyl-1,2-dihydroquinoline-6-carboxaldehyde수율 78%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester (200 mg, 0.61 mmol), 10% HCl (1 mL) and dioxane (3 mL) was heated to reflux for 48 h. After cooling, water was added and the resulting precipitate was collected by filtration, washed with water and dried to afford 6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid (a) (143 mg, 78%). MS: 300.5 (M+H).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 48 h
  3. temperatureAfter cooling
  4. filtrationthe resulting precipitate was collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-dfcf3c603a164719bea5234769eb7fd5
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326788B2

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