Hydrochloric Acid → HCID 68569999, 화합물

HRID 2053523

반응식

HRID 2053523 반응식
[ClH:1].C(OC([N:9]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]=[C:10]1[N:26]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:27])=O)(C)(C)C>CCOC(C)=O>[ClH:1].[C:14]1([C@H:13]2[C@@H:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][C:10]([N:26]([CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH3:27])=[N:9]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 685697692-(N-Methylbenzylamino)-cis-4,5-diphenyl-4,5-dihydro-imidazole-1-carboxylic Acid Tert-Butyl Ester

생성물 1

HCID 68569999HCID 68569999, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Hydrogen chloride is bubbled into a solution of 81 (110 mg, 0.25 mmol) in EtOAc (10 mL) for 1 min, and the solution is stirred at RT for 6 h. The solvent is removed by rotary evaporation, and the residue triturated with Et2O. The insoluble material is dissolved in dichloromethane and Et2O is added, and the precipitate is filtered to give 43 mg of the product 82. 1H NMR (DMSO-d6) δ 9.28 (s, 2H), 7.60-7.30 (m, 5H), 7.25-6.95 (m, 10H), 5.58 (s, 2H), 4.78 (s, 2H), 3.15 (s, 3H); MS: m/z 342 (M++1).

후처리

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue triturated with Et2O
  3. dissolutionThe insoluble material is dissolved in dichloromethane
  4. additionEt2O is added
  5. filtrationthe precipitate is filtered

출처 및 근거

ORD 기록
ord-6d41629badbf44e9a104e75b090b92c9
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326792B2

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