Tert-Butylamine → N-tert-Butyl-N-(trimethylsilylmethyl)amine
반응식
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9].[OH-].[Na+]>>[C:1]([NH:5][CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]참가 물질
4
반응 조건
- 온도
- 200 °C
실험 절차
A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 1-1 as a colorless liquid.
후처리
- temperatureAfter cooling to ambient temperature
- extractionextracted three times with diethyl ether
- washThe combined organic extracts were washed with brine
- dry with materialdried (MgSO4)
- customthe volatiles evaporated in vacuo
- distillationDistillation (atmospheric pressure; ˜135° C.) of the residual liquid
출처 및 근거
- ORD 기록
- ord-4edf1ab381704ed387738872f830a54b
- 출처 데이터셋
- uspto-grants-2008_02
- 특허 번호
- US07329673B2
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