hydroxylamine-O-sulfonic acid → 3-Bromo-5-methylthiophene-2-carbonitrile
반응식
[Br:1][C:2]1[CH:6]=[C:5]([CH3:7])[S:4][C:3]=1[CH:8]=O.[NH2:10]OS(O)(=O)=O>O>[Br:1][C:2]1[CH:6]=[C:5]([CH3:7])[S:4][C:3]=1[C:8]#[N:10]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To a suspension of 3-bromo-5-methyl-2-thiophenecarboxaldehyde (500 mg) in water (10 ml) was added hydroxylamine-O-sulfonic acid (330 mg). The mixture was heated to 50° C. for 12 h and allowed to cool. The mixture was then extracted with ethyl acetate (3×50 ml). The combined organic layers were washed (brine), dried (MgSO4), filtered and evaporated to leave the sub-title compound (410 mg) as a brown solid.
후처리
- temperatureto cool
- extractionThe mixture was then extracted with ethyl acetate (3×50 ml)
- washThe combined organic layers were washed (brine)
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-203885634b22458bb48375919679ef63
- 출처 데이터셋
- uspto-grants-2008_02
- 특허 번호
- US07329686B2
반응 노트
불러오는 중…