Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

HRID 2054693

반응식

HRID 2054693 반응식
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1>CC(C)=O.CCOCC>[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 9885359{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

생성물 1

HCID 131726767{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

시약·촉매·용매 2

HCID 180Acetone용매HCID 3283Diethyl Ether용매

실험 절차

For salt formation, 1N hydrochloric acid is added to a solution of {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone in 60 ml of acetone and 50 ml of ether until crystals form. When crystallisation is complete, the mother liquor is filtered off, and the precipitate is washed with ether and dried, giving {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride, m.p. 238-240°.

후처리

  1. customform
  2. customWhen crystallisation
  3. filtrationthe mother liquor is filtered off
  4. washthe precipitate is washed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-d0a23f68871b41f4a282286bf96a4ab9
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329749B2

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