Sodium Hydroxide → HCID 178461815, 화합물

HRID 20547

반응식

HRID 20547 반응식
[OH:1][CH2:2][C@H:3]([CH3:31])[O:4][C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:23]([NH:25][C:26]2[CH:30]=[CH:29][NH:28][N:27]=2)=[O:24])[CH:22]=1)[O:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][CH:10]=1.[OH-].[Na+]>C1COCC1.O>[OH:1][CH2:2][C@H:3]([CH3:31])[O:4][C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:23]([NH:25][C:26]2[CH:30]=[CH:29][NH:28][N:27]=2)=[O:24])[CH:22]=1)[O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[CH:18][CH:19]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 178469074HCID 178469074, 화합물

생성물 1

HCID 178461815HCID 178461815, 화합물수율 86.8%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of ethyl 4-{3-[(1S)-2-hydroxy-1-methylethoxy]-5-[(1H-pyrazol-3-ylamino)carbonyl]phenoxy}benzoate (175 mg, 0.4 mmol) in THF (5 mL) and water (1 mL) was treated with 1N sodium hydroxide solution (3 mL) and the reaction stirred at RT for 16 hours. On completion, the solvent was removed in vacuo and 1N citric acid added until pH 3-4. The white precipitate was collected by filtration and dried in vacuo to give the desired product as a white solid (138 mg, 85%).

후처리

  1. customOn completion, the solvent was removed in vacuo and 1N citric acid
  2. additionadded until pH 3-4
  3. filtrationThe white precipitate was collected by filtration
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-f71922eafb5c4170ae05152f347a6481
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745475B2

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