Water → HCID 21948877, 화합물

HRID 2054981노트

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HRID 2054981 반응식
[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N:16]=[CH:17][C:18]([C:33]([F:36])([F:35])[F:34])([OH:32])[CH2:19][C:20]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[O:30][CH3:31])([CH3:22])[CH3:21])[N:7]=1)(=[O:3])[CH3:2].[BH4-].[Na+].O>CO.O1CCCC1>[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH:16][CH2:17][C:18]([C:33]([F:34])([F:35])[F:36])([OH:32])[CH2:19][C:20]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[O:30][CH3:31])([CH3:22])[CH3:21])[N:7]=1)(=[O:3])[CH3:2]

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21948882HCID 21948882, 화합물

생성물 1

HCID 21948877HCID 21948877, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution that consists of 170 mg (0.34 mmol) of 1-(2-(acetoxymethyl)quinolin-5-ylimino)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)pentan-2-ol in 1.5 ml of methanol and 0.8 ml of tetrahydrofuran is mixed with 53 mg (1.38 mmol) of sodium borohydride. After 3 hours at room temperature, the reaction is halted by adding water. It is extracted with ethyl acetate, the combined organic phases are washed with saturated sodium chloride solution and dried on sodium sulfate. After removal of the solvent and chromatography on silica gel with hexane-ethyl acetate (0-100%), 94 mg (55% of theory) of the product is obtained.

후처리

  1. extractionIt is extracted with ethyl acetate
  2. washthe combined organic phases are washed with saturated sodium chloride solution
  3. customdried on sodium sulfate
  4. customAfter removal of the solvent and chromatography on silica gel with hexane-ethyl acetate (0-100%), 94 mg (55% of theory) of the product
  5. customis obtained

출처 및 근거

ORD 기록
ord-e71d9fa673074c77bf3ff13108ac51e6
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329753B2

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