Sodium Hydroxide → 3-(Pyridin-4-yl)butanoic acid
반응식
[OH-].[Na+].[CH3:3][CH:4]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH2:5][C:6]([O:8]CC)=[O:7]>CO.O>[CH3:3][CH:4]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[CH2:5][C:6]([OH:8])=[O:7]참가 물질
5
실험 절차
Sodium hydroxide (0.19 g, 4.8 mmol) was added to a solution of ethyl 3-methyl-3-pyridin-4-ylpropanoate (Method 8; 0.501 g, 2.6 mmol) in MeOH (10 ml) and water (5 ml). The mixture was stirred at room temperature for 18 hours. The solvent was removed in vacuc and the residue shaken with 1 M hydrochloric acid (4.8 ml). The solvent was removed in vacuo to leave a colourless solid. M/z′164 (M-H)−.
후처리
- customThe solvent was removed in vacuc
- stirringthe residue shaken with 1 M hydrochloric acid (4.8 ml)
- customThe solvent was removed in vacuo
- customto leave a colourless solid
출처 및 근거
- ORD 기록
- ord-5a041dda89f346ea97fe44f785edbc6d
- 출처 데이터셋
- uspto-grants-2008_02
- 특허 번호
- US07332492B2
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