Formamide → HCID 135553012, 화합물

반응식

[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]

참가 물질

반응물 2

HCID 713Formamide

HCID 117799312-Amino-3-bromo-5-chlorobenzoic acid

생성물 1

HCID 135553012HCID 135553012, 화합물

실험 절차

8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+

후처리

temperatureat reflux overnight
temperatureThe mixture was cooled
customquenched with water
customThe solid that formed
washwas washed with acetonitrile, 6.7 g crude (65%)

출처 및 근거

ORD 기록: ord-4dd82de2a8234fc5b58672625743b906
출처 데이터셋: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07332506B2

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