HCID 11287642, 화합물 → 3-(Carboxymethoxy)isoxazole-5-carboxylic acid

HRID 2056266노트

반응식

HRID 2056266 반응식
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:6]=1)=[O:4]>CO.[OH-].[Na+]>[C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH:6]=1)([OH:4])=[O:2]

참가 물질

4

반응물 1

HCID 11287642HCID 11287642, 화합물

생성물 1

HCID 111481453-(Carboxymethoxy)isoxazole-5-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of ethyl (5-(methoxycarbonyl)isoxazol-3-yl)oxyacetate (4 mmol, Example 73) in methanol (60 mL) and 5% aqueous NaOH is heated at reflux for 1 hour. At the end of this time, the methanol is removed, the residue diluted with additional water, and acidified to pH=4 with hydrochloric acid. The resulting precipitate is collected by filtration, washed with cold water, and dried.

후처리

  1. temperatureat reflux for 1 hour
  2. customAt the end of this time, the methanol is removed
  3. additionthe residue diluted with additional water
  4. filtrationThe resulting precipitate is collected by filtration
  5. washwashed with cold water
  6. customdried

출처 및 근거

ORD 기록
ord-12f1b06ac18f4c0ab03fe67d2a7285d8
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335655B2

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