1,4-Dibromobutane → (1R,2S)-1,2-Diphenyl-2-piperidin-1-yl-ethanol

HRID 2057116노트

반응식

HRID 2057116 반응식
N[C@@H:2]([CH:11](C)[CH3:12])[C@@H:3]([C:5]1C=CC=CC=1)O.[NH2:14][C@@H:15]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C@@H:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[OH:17].BrCCCCBr.BrCCCCCBr>CCOC(C)=O.CCCCCC>[C:18]1([C@@H:16]([OH:17])[C@H:15]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:14]2[CH2:12][CH2:11][CH2:2][CH2:3][CH2:5]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

7

반응물 4

HCID 80561,4-DibromobutaneHCID 81001,5-DibromopentaneHCID 719819(1R,2S)-2-Amino-1,2-diphenylethanolHCID 10856884HCID 10856884, 화합물

생성물 1

HCID 23251237(1R,2S)-1,2-Diphenyl-2-piperidin-1-yl-ethanol수율 91%

시약·촉매·용매 2

HCID 8058Hexane용매HCID 8857Ethyl Acetate용매

실험 절차

Repeat Step (a) of EXAMPLE 6, but replace (1R,2S)-2-amino-1-phenyl-3-methyl-butanol with (1R,2S)-2-amino-1,2-diphenyl-ethanol, and replace 1,4-dibromobutane with 1,5-dibromopentane. Column chromatography (Silica gel 50 g, eluent is n-Hexane:EtOAc=5:1) is used to purify the coarse product and a white solid (1.28 g) is obtained. The yield is 91% and the other analysis includes:

후처리

  1. customto purify the coarse product

출처 및 근거

ORD 기록
ord-dbb0a5219dd449938eda2e8b584573b7
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335781B2

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