Hydrochloric Acid → HCID 178468267, 화합물

HRID 2057343노트

반응식

[C:1]([CH2:3][CH2:4][CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:9][CH2:8]1)#[N:2].Cl.[CH2:29]([OH:31])[CH3:30]>>[CH2:29]([O:31][C:1](=[NH:2])[CH2:3][CH2:4][CH2:5][O:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:11][CH2:12]1)[CH3:30]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 178484853HCID 178484853, 화합물

생성물 1

HCID 178468267HCID 178468267, 화합물

실험 절차

0.35 g (0.87 mmol) trans-N-[4-(3-Cyano-propoxy)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide in 6 ml ethanol were treated with HCl gas at low temperature for 20 min. The mixture was kept at −20° C. for 48 h, was concentrated under reduced pressure to yield 400 mg (quant.) trans-4-{4-[Methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-cyclohexyloxy}-butyrimidic acid ethyl ester as light brown oil, MS: 451 (MH+).

후처리

concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-ac17f8f7e57d43008944ac82510b64d7
출처 데이터셋: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07335687B2

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