Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2057845노트

반응식

HRID 2057845 반응식
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

생성물 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

시약·촉매·용매 2

HCID 16218511Pd barium sulfate촉매HCID 887Methanol용매

실험 절차

300 g (778 mmoles) of Z-Tyr(But)-OMe (Ann. Chem. 696, 226 (1966)) are dissolved in 1 liter of methanol and hydrogenated catalytically (Pd/BaSO4 catalyst) at pH 4.5, using an auto-burette (about 2 N methanolic HCl being added). After completion of hydrogenation, the catalyst is filtered off and the filtrate is concentrated. The residue is triturated with ether.

후처리

  1. filtrationAfter completion of hydrogenation, the catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customThe residue is triturated with ether

출처 및 근거

ORD 기록
ord-1056f3f79e874fd4a3a7c1eba6adf64f
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04212796

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