N-bromobutanimide → Ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate

HRID 2058075노트

반응식

HRID 2058075 반응식
[C:1]1([CH3:16])[CH:6]=[CH:5][C:4]([O:7][C:8]([CH3:15])([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.[Br:17]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:17][CH2:16][C:1]1[CH:6]=[CH:5][C:4]([O:7][C:8]([CH3:15])([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 1531788Ethyl 2-methyl-2-(4-methylphenoxy)propanoate

생성물 1

HCID 12870372Ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate수율 67.5%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

(a) A mixture of 20 g of ethyl 2-(p-tolyloxy)-2-methylpropionate, 17.7 g of N-bromosuccinimide, 0.2 g of benzoyl peroxide and 140 ml of anhydrous carbon tetrachloride is refluxed under heating for 4 hours. After the reaction, the reaction mixture is left to stand for cooling and washed with water. The carbon tetrachloride layer is dried and then concentrated. The resulting oily product (28 g) is distilled under reduced pressure to give 18.3 g of ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate, bp 146° to 148° C./1-2 mmHg.

후처리

  1. temperatureis refluxed
  2. temperatureunder heating for 4 hours
  3. customAfter the reaction
  4. waitthe reaction mixture is left
  5. temperaturefor cooling
  6. washwashed with water
  7. dry with materialThe carbon tetrachloride layer is dried
  8. concentrationconcentrated
  9. distillationThe resulting oily product (28 g) is distilled under reduced pressure

출처 및 근거

ORD 기록
ord-ec106db9c730455e99d7402e9f187a82
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04214094

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