Sodium Hydroxide → 2-[4-{N-(4-chlorophenyl)-N-methylaminomethyl}phenoxy]-2-methylpropionic acid

HRID 2058091노트

반응식

HRID 2058091 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:13][CH:12]=2)[CH3:9])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:22])([CH3:23])[C:17]([OH:19])=[O:18])=[CH:24][CH:25]=2)[CH3:9])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20329844ethyl 2-[4-{N-(4-chlorophenyl)-N-methylaminomethyl}phenoxy]-2-methylpropionate

생성물 1

HCID 203298602-[4-{N-(4-chlorophenyl)-N-methylaminomethyl}phenoxy]-2-methylpropionic acid수율 84.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In 20 ml of ethanol is dissolved 1.2 g of ethyl 2-[4-{N-(4-chlorophenyl)-N-methylaminomethyl}phenoxy]-2-methylpropionate. Subsequently, 15 ml of 1 N aqueous solution of sodium hydroxide is added to the solution, and the mixture is stirred at room temperature for 4 hours. After distilling off the ethanol from the reaction mixture under reduced pressure, the residue is dissolved in water. The solution is adjusted to pH 4 with 10% hydrochloric acid, and the precipitated crystals are collected by filtration and dried to give 0.94 g of 2-[4-{N-(4-chlorophenyl)-N-methylaminomethyl}phenoxy]-2-methylpropionic acid, mp 63° to 65° C.

후처리

  1. distillationAfter distilling off the ethanol from the reaction mixture under reduced pressure
  2. dissolutionthe residue is dissolved in water
  3. filtrationthe precipitated crystals are collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-e9885f5d0869494db556ad50fa0b5b4e
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04214094

반응 노트

불러오는 중…