Hydrochloric Acid → 1-Hydroxy-3-(hydroxymethyl)-8-methoxyanthracene-9,10-dione

HRID 2058149노트

반응식

HRID 2058149 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:16]=1[C:15](=[O:17])[C:14]1[C:13]([O:18]C(=O)C)=[CH:12][C:11]([CH2:22][O:23]C(=O)C)=[CH:10][C:9]=1[C:8]2=[O:27].Cl.O>CO>[OH:18][C:13]1[C:14]2[C:15](=[O:17])[C:16]3[C:7](=[CH:6][CH:5]=[CH:4][C:3]=3[O:2][CH3:1])[C:8](=[O:27])[C:9]=2[CH:10]=[C:11]([CH2:22][OH:23])[CH:12]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10406699HCID 10406699, 화합물

생성물 1

HCID 233496281-Hydroxy-3-(hydroxymethyl)-8-methoxyanthracene-9,10-dione수율 70.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The 8-methoxy-3-acetoxymethyl-1-acetoxy anthraquinone (120 mg) of Example 22 was refluxed in methanol (30 ml) with concentrated hydrochloric acid (10 ml) and water (10 ml) for three hours. The solvents and acid were evaporated off in vacuum and the residue crystallized from chloroform to obtain reddish yellow crystals (65 mg) of 1-hydroxy-3-hydroxymethyl-8-methoxy anthraquinone (formula 19). m.p. 215°-216°, ir (KBr) 3520-3460, 1670, 1635, 1585 cm-1.

후처리

  1. customThe solvents and acid were evaporated off in vacuum
  2. customthe residue crystallized from chloroform

출처 및 근거

ORD 기록
ord-7c77745ef05a4cd1b27c4521c52b6407
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04215062

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