Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2058398노트

반응식

HRID 2058398 반응식
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

생성물 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

시약·촉매·용매 2

HCID 16218511Pd barium sulfate촉매HCID 887Methanol용매

실험 절차

300 g (778 mmols) of Z-Tyr(But)-OMe (Ann. Chem. 696, page 226 (1966)) were dissolved in 1 l of methanol and catalytically hydrogenated (Pd/BaSO4 catalyst) at pH 4.5 on the autoburette (addition of about 2 N methanolic HCl). When the hydrogenation was complete, the catalyst was filtered off with suction and the filtrate was concentrated. The residue was triturated with ether.

후처리

  1. filtrationthe catalyst was filtered off with suction
  2. concentrationthe filtrate was concentrated
  3. customThe residue was triturated with ether

출처 및 근거

ORD 기록
ord-fc7ece1ab4804c53a69a69978249eb9c
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04215037

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