4-Fluorobenzenesulfonyl chloride → Azetidine, 1-[(4-fluorophenyl)sulfonyl]-

HRID 20584

반응식

HRID 20584 반응식
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1>C1COCC1>[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH2:4][CH2:3][CH2:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 10422Azetidine

생성물 1

HCID 59346928Azetidine, 1-[(4-fluorophenyl)sulfonyl]-수율 8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Azetidine (0.25 g, 4.35 mmol) was added to a solution of sodium hexamethyldisilylazide (0.85 g, 4.6 mmol) in THF (10 mL) at 0° C. and reaction mixture stirred for 10 minutes. 4-fluorobenzenesulfonyl chloride (0.85 g, 4.35 mmol) was subsequently added and the reaction mixture was allowed to warm up to ambient temperature overnight. The reaction mixture was concentrated in vacuo and the residue taken up in ethyl acetate and water. The organic layer was separated and then dried (MgSO4), filtered and evaporated to give a waxy, yellow solid (75 mg).

후처리

  1. customreaction mixture
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customThe organic layer was separated
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-c32ba789be974ba99759bf5cf8743db1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745475B2

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