Sodium Hydroxide → 6-{[2-Tetrahydrofuranylamino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt

HRID 2058416노트

반응식

HRID 2058416 반응식
[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].O.O.O.C[C:30]1([CH3:53])S[C@@H]2[C@H](NC([C@H](N)C3C=CC(O)=CC=3)=O)C(=O)N2[C@H:31]1[C:50](O)=[O:51].O1CCCC1O.[OH-].[Na+:61]>O>[Na+:61].[O:51]1[CH2:50][CH2:31][CH2:30][CH:53]1[NH:21][CH:13]([C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[C:11]([NH:10][CH:7]1[C:8](=[O:9])[N:4]2[CH:5]1[S:6][C:2]([CH3:25])([CH3:1])[CH:3]2[C:22]([O-:24])=[O:23])=[O:12]

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 33613AmoxicillinHCID 62883Amoxicillin TrihydrateHCID 93002Tetrahydro-2-hydroxyfuran

생성물 1

HCID 778728506-{[2-Tetrahydrofuranylamino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt

시약·촉매·용매 1

HCID 962Water용매

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온도
25 °C

실험 절차

To a stirred suspension of 6.28 g (0.015) mol) of amoxicillin trihydrate in 150 ml of distilled water was added in one portion 15 ml of 1 N aqueous sodium hydroxide solution. The amoxicillin quickly dissolved and after two minutes 2.25 g (0.025 mol) of tetrahydro-2-furanol was added. After stirring at 25° C. for two minutes the solution was quickly frozen by means of a dry ice-acetone bath and then lyophilized for 22 hr. The resulting product {2S-[2α, 5α, 6β(S*)]}-6-{[2-tetrahydrofuranylamino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt (6.55 g) was obtained as a white powder.

후처리

  1. additionwas added
  2. temperaturewas quickly frozen by means of a dry ice-acetone bath
  3. waitlyophilized for 22 hr

출처 및 근거

ORD 기록
ord-aa69cc97006d4a90989d523f7ca23f10
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04317775

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