Hydrochloric Acid → HCID 70515775, 화합물

HRID 2058543노트

반응식

HRID 2058543 반응식
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[CH:4][S:5][C:6]=1[CH2:7][CH3:8].[ClH:12].[CH:13](O)([CH3:15])[CH3:14]>>[ClH:12].[CH:13]([O:10][C:9]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH3:8])[S:5][CH:4]=1)=[O:11])([CH3:15])[CH3:14]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 132861554-Amino-5-ethylthiophene-3-carboxylic acid

생성물 1

HCID 70515775HCID 70515775, 화합물

실험 절차

A sample of 1.02 g. (4.610 mmols) of 4-amino-5-ethyl-3-thiophenecarboxylic acid was dissolved in 50 ml. of isopropanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 48 hours, cooled and evaporated to afford 0.927 g. (81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isoprpopanol/ether.

후처리

  1. customThe resulting reaction
  2. temperaturewas heated
  3. temperatureunder reflux for 48 hours
  4. temperaturecooled
  5. customevaporated
  6. customto afford 0.927 g
  7. custom(81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isoprpopanol/ether

출처 및 근거

ORD 기록
ord-f8d734479dae4dd4b8d467a5adbad9b1
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04317915

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