Tris(2-chloroethyl)amine → Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

반응식

Cl[CH2:2][CH2:3][N:4]([CH2:8][CH2:9]Cl)[CH2:5][CH2:6]Cl.[CH3:11][O:12][CH2:13][CH2:14][OH:15]>>[CH2:3]([N:4]([CH2:8][CH2:9][O:15][CH2:14][CH2:13][O:12][CH3:11])[CH2:5][CH2:6][O:15][CH2:14][CH2:13][O:12][CH3:11])[CH2:2][O:15][CH2:14][CH2:13][O:12][CH3:11]

참가 물질

반응물 2

HCID 5561Tris(2-chloroethyl)amine

HCID 80192-Methoxyethanol

생성물 1

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

실험 절차

To the aforesaid reaction mixture (i), 51.6 g tris(2-chloroethyl)amine chlorhydrate (0.215 moles) were added. The mixture was then heated with reflux of 2-methoxyethanol (125° C.) for 12 hours, followed by the distillation of the solvent under reduced pressure. The excess sodium 2-methoxyethanolate was then neutralized by addition of 11.6 cm3 aqueous HCl (10 N). The sodium chloride was filtered off and the solution distilled.

후처리

additionwere added
temperatureThe mixture was then heated
distillationfollowed by the distillation of the solvent under reduced pressure
additionThe excess sodium 2-methoxyethanolate was then neutralized by addition of 11.6 cm3 aqueous HCl (10 N)
filtrationThe sodium chloride was filtered off
distillationthe solution distilled

출처 및 근거

ORD 기록: ord-3afec1d7478842e7b19584f7dd5ff4f3
출처 데이터셋: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04322369

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