Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxyamine hydrochloride → 3-(3-(Trifluoromethyl)phenyl)-1,2-oxazol-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 3-(Trifluoromethyl)benzoylacetonitrile | HCID 520304 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(3-(Trifluoromethyl)phenyl)-1,2-oxazol-5-amine | HCID 13035544 | — |
반응 단계
3-(Trifluoromethyl)benzoylacetonitrile (3.8 grams) and 125 ml. ethanol were placed in a 500 ml. flask. The solution was treated with sodium acetate (12 grams) and hydroxylamine.hydrochloride (9 grams in 125 ml. water) and then heated to reflux for two hours. After cooling to room temperature, the ethanol was removed and the residue extracted with ether. The ether extracts were then washed with water, brine, and dried with MgSO4. The solid residue obtained was recrystallized from an ethanol/water solution, m.p. 89°-90° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04322429 |
| 출처 데이터셋 | uspto-grants-1982_03 |
| ORD ID | ord-7523057963bb400c8ce725c409847f9a |
| 출처 메모 | uspto-grants-1982_03 |