Acetic Anhydride → HCID 86738324, 화합물

HRID 2059303노트

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HRID 2059303 반응식
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:17]([CH2:18][CH2:19][C@:3]12[CH3:4])[C@:16]1([CH2:20][C:21]#[CH:22])[C:11](=[CH:12][C:13](=[O:23])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[C:24]([O:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:17]([CH2:18][CH2:19][C@:3]12[CH3:4])[C@:16]1([CH2:20][C:21]#[CH:22])[C:11](=[CH:12][C:13](=[O:23])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3)(=[O:26])[CH3:25]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 86738323HCID 86738323, 화합물

생성물 1

HCID 86738324HCID 86738324, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 500 mg of 17β-hydroxy-10-(2-propynyl)estr-4-en-3-one in 4 ml of pyridine at 25° C. is added 4 ml of acetic anhydride and the mixture is allowed to stand at room temperature for 16 hours. It is then concentrated under reduced pressure, the residue is diluted with ether and the ether solution is washed with 1 N hydrochloric acid and with aqueous sodium bicarbonate and then dried and concentrated. The resultant residue is recrystallized from ethyl acetate-hexane to give 17β-acetoxy-10-(2-propynyl)estr-4-en-3-one. This compound has the following structural formula ##STR10##

후처리

  1. concentrationIt is then concentrated under reduced pressure
  2. additionthe residue is diluted with ether
  3. washthe ether solution is washed with 1 N hydrochloric acid and with aqueous sodium bicarbonate
  4. customdried
  5. concentrationconcentrated
  6. customThe resultant residue is recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-d464cc13a68645ad85b336cfb766da39
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04322416

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