4-(Trifluoromethyl)benzaldehyde → 201164-14-9

HRID 2059450노트

반응식

HRID 2059450 반응식
O=Cc1ccc(C(F)(F)F)cc1.CON(C)C(=O)CC(=O)O>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.CN(C)C=O>CON(C)C(=O)/C=C/c1ccc(C(F)(F)F)cc1

참가 물질

6

반응물 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 11263568HCID 11263568, 화합물

생성물 1

HCID 9449823201164-14-9수율 71%

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine시약HCID 12484433Benzenemethanamine, trifluoroacetate촉매HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

후처리

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 상 유지
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

출처 및 근거

ORD 기록
ord-983bcc712e8641be92d7f0dabc0d5b50
출처 데이터셋
Transfer learning optimization of 26 decarboxylative olefination reactions

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