3-Methoxy-3-oxopropanoic acid → HCID 178500105, 화합물

HRID 2059480노트

반응식

HRID 2059480 반응식
COC(=O)CC(=O)O.COc1ccc2c(c1)c(CC=O)c(C)n2C(=O)c1ccc(Cl)cc1>C1COCCN1.CN(C)c1ccncc1.C1CCOC1>COC(=O)/C=C/Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

참가 물질

6

반응물 2

HCID 5383663-Methoxy-3-oxopropanoic acidHCID 20158193[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetaldehyde

생성물 1

HCID 178500105HCID 178500105, 화합물수율 80%

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine시약HCID 8083Morpholine촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

후처리

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 상 유지
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

출처 및 근거

ORD 기록
ord-9e531918475e43bb95313495bd1ca7a6
출처 데이터셋
Transfer learning optimization of 26 decarboxylative olefination reactions

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