Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 2059964

반응식

HRID 2059964 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

생성물 1

HCID 2474Bupivacaine (USAN:INN:BAN)

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (1 N solution) was added to the solution and the pH of the final mixtures was adjusted to 10 to precipitate the BP bate. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at approximately 40° C. in vacuum for 24 h.

후처리

  1. customto precipitate the BP bate
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at approximately 40° C. in vacuum for 24 h.

출처 및 근거

ORD 기록
ord-bbe0ae0487d0453db13663838e0d921d
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278330B2

연결된 노트

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