Acetic Anhydride → 1-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

HRID 2059975노트

반응식

HRID 2059975 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[CH2:5][C:6]1=[O:11])(=[O:14])[CH3:13]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 583867501-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

실험 절차

At 170° C. 3.0 g (20 mmol) 5-fluoroindolinone were stirred in 10 mL (98 mmol) acetic anhydride for 3 h. After cooling to RT the mixture was poured onto 200 mL ice water, the precipitated substance was suction filtered and washed with 100 mL water. The solid was recrystallised from water and ethanol. The precipitated product was suction filtered, washed with water and dried i. vac.

후처리

  1. customAt 170° C
  2. filtrationfiltered
  3. washwashed with 100 mL water
  4. customThe solid was recrystallised from water and ethanol
  5. filtrationfiltered
  6. washwashed with water
  7. customdried i

출처 및 근거

ORD 기록
ord-0d84cf368835448cad78b1bb742f3fce
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278336B2

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