Sodium Hydroxide → HCID 68802039, 화합물

HRID 2060071노트

반응식

HRID 2060071 반응식
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=2)[C:7]1=[O:20])[CH3:4].[OH-].[Na+]>O>[CH3:4][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:17])[F:18])[CH:12]=2)[C:7]1=[O:20])[CH3:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 694507812-Dimethylaminomethyl-5-trifluoromethoxy-indan-1-one hydrochloride

생성물 1

HCID 68802039HCID 68802039, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

14 g of the product from step 3 were dissolved in water; the solution was adjusted to pH 12 with 32% sodium hydroxide solution, while cooling with ice, and extracted three times with dichloromethane, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated in vacuo.

후처리

  1. temperaturewhile cooling with ice
  2. extractionextracted three times with dichloromethane
  3. dry with materialthe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-778622f470074d93814ea356c2bf25bd
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278338B2

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