Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 7-Bromo-1-chloro-6-methoxyisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 7-Bromo-6-methoxy-1(2H)-isoquinolinone | HCID 58005125 | — |
| 생성물 | 7-Bromo-1-chloro-6-methoxyisoquinoline | HCID 59571146 | — |
반응 단계
A mixture of the product from Step 2 (7-bromo-6-methoxyisoquinolin-1(2H)-one) (4.7 g, 18.5 mmol) in phosphorus oxychloride (30 mL) was heated to reflux for 2 h, cooled to RT, the volatiles evaporated and the residue partitioned between 3M NaOH and DCM. The organic phase was dried over Na2SO4, solvent evaporated and the solid triturated with Et2O (20 mL) and filtered to give a solid (3.75 g). LRMS ESI+ (M+H)+ 274.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08278322B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-17e8341d8d9d4154bc30772648a13051 |
| 출처 메모 | uspto-grants-2012_10 |