反应详情

A mixture of the product from Step 2 (7-bromo-6-methoxyisoquinolin-1(2H)-one) (4.7 g, 18.5 mmol) in phosphorus oxychloride (30 mL) was heated to reflux for 2 h, cooled to RT, the volatiles evaporated and the residue partitioned between 3M NaOH and DCM. The organic phase was dried over Na2SO4, solvent evaporated and the solid triturated with Et2O (20 mL) and filtered to give a solid (3.75 g). LRMS ESI+ (M+H)+ 274.0.

1. temperaturewas heated
2. temperatureto reflux for 2 h
3. customthe volatiles evaporated
4. customthe residue partitioned between 3M NaOH and DCM
5. dry with materialThe organic phase was dried over Na2SO4, solvent
6. customevaporated
7. customthe solid triturated with Et2O (20 mL)
8. filtrationfiltered