Hydrochloric Acid → 4-(Trifluoromethyl)cyclohexan-1-amine hydrochloride

HRID 2060870노트

반응식

HRID 2060870 반응식
C([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]1)C1C=CC=CC=1.[ClH:19]>CO.O1CCOCC1.[Pd]>[ClH:19].[F:16][C:15]([F:17])([F:18])[CH:12]1[CH2:11][CH2:10][CH:9]([NH2:8])[CH2:14][CH2:13]1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 43434579Benzyl(4-trifluoromethylcyclohexyl)amine

생성물 1

HCID 187699224-(Trifluoromethyl)cyclohexan-1-amine hydrochloride

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

A solution of benzyl(4-trifluoromethylcyclohexyl)amine (Preparation 4) (1.48 g, 5.73 mmol) in MeOH (150 mL) was passed through an H-Cube at 100° C. fitted with a 10% Pd/C CatCart and on full H2 mode. The volume was reduced to 50 mL and 4M HCl in dioxane (1.43 mL) was added. The precipitate was filtered, the filtrate collected and the solvent removed in vacuo. The resulting residue was triturated with acetone to give the title compound: δH (CD3OD) 1.41-1.53 (4H, m), 2.03-2.25 (5H, m), 3.07-3.15 (1H, m).

후처리

  1. customwas passed through an H-Cube at 100° C.
  2. additionwas added
  3. filtrationThe precipitate was filtered
  4. customthe filtrate collected
  5. customthe solvent removed in vacuo
  6. customThe resulting residue was triturated with acetone

출처 및 근거

ORD 기록
ord-2d9a4257b37e4839b42c5275f1a5e409
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278442B2

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