Methyl iodide → HCID 68651293, 화합물

HRID 2060964노트

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HRID 2060964 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[C:9]([O:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])=[C:8]3[NH:21][C:22]4[CH:23]=[CH:24][C:25]([F:28])=[CH:26][C:27]=4[C:7]3=[CH:6][C:5]2=1.[CH3:29][I:30]>ClCCl>[I-:30].[F:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:8]1[C:9]([O:15][CH2:16][CH2:17][N+:18]([CH3:29])([CH3:19])[CH3:20])=[C:10]3[NH:11][C:12]4[CH:13]=[CH:14][C:2]([F:1])=[CH:3][C:4]=4[C:5]3=[CH:6][C:7]2=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 45138929HCID 45138929, 화합물

생성물 1

HCID 68651293HCID 68651293, 화합물수율 62%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(2,10-difluoro-5,7-dihydroindolo[2,3-b]carbazol-6-yloxy)-N,N-dimethylethanamine (14 mg) in dichloromethane (8 mL) was added MeI (1.0 mL) at RT under Ar. The resultant solution was stirred overnight and the solid formed. The solid was collected by filtration and washed once with dichloromethane and dried under vacuum to give the title compound (12 mg, 62%). 1H NMR (400 MHz, CD3OD) δ ppm 8.51 (s, 1H), 7.84 (dd, J=9.2, 2.8 Hz, 2H), 7.44 (dd, J=8.8, 4.0 Hz, 2H), 7.12 (ddd, J=9.2, 9.6, 2.4 Hz, 2H), 4.75-4.68 (m, 2H), 4.12-4.07 (m, 2H), 3.46 (s, 9H); MS (ESI) e/z 394 (M−I)+.

후처리

  1. customthe solid formed
  2. filtrationThe solid was collected by filtration
  3. washwashed once with dichloromethane
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-81758a82a9fd4bf19443104f862e7a72
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278341B2

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