Phosphorus tribromide → 1-(Bromomethyl)-2-fluoro-3-nitrobenzene

HRID 2061126노트

반응식

HRID 2061126 반응식
P(Br)(Br)[Br:2].[F:5][C:6]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:15]O>C(OCC)C>[Br:2][CH2:15][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]([N+:12]([O-:14])=[O:13])[C:6]=1[F:5]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 29919768(2-Fluoro-3-nitrophenyl)methanol

생성물 1

HCID 591391511-(Bromomethyl)-2-fluoro-3-nitrobenzene수율 70%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
0 °C

실험 절차

A solution of phosphorus tribromide (4.8 mL) in anhydrous diethylether (100 mL) was added at 0° C. to a solution of (2-fluoro-3-nitrophenyl)methanol (compound 2c-1) (7.52 g, 46.3 mmol) in anhydrous diethylether (130 mL), and the mixture was stirred at 30 minutes at 0° C. The reaction mixture was then poured into ice water and extracted with ethyl acetate. The organic extract was washed in series with saturated sodium hydrogen carbonate solution, water and saturated saline, and dried over magnesium sulfate. The title compound (7.10 g, 70%) was then obtained as a brown oil.

후처리

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. washwas washed in series with saturated sodium hydrogen carbonate solution, water and saturated saline
  4. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-556711d65878497e8c6f0bfef069f595
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278465B2

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