Tert-Butylamine → 4-(tert-Butylamino)-4-oxobutanoic acid

HRID 2061233노트

반응식

HRID 2061233 반응식
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[C:8]([NH2:12])([CH3:11])([CH3:10])[CH3:9]>ClCCl>[C:8]([NH:12][C:1](=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5])([CH3:11])([CH3:10])[CH3:9]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 7922Succinic anhydride

생성물 1

HCID 2450094-(tert-Butylamino)-4-oxobutanoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.07 g (30.6 mmol) of succinic anhydride was suspended in 30 ml of dichloromethane. 4.1 ml (34.5 mmol) of t-butylamine was dropped into the suspension, and the resultant mixture was stirred at room temperature for 1 hour. White crystals thus formed were washed with ethyl acetate and then dissolved in 40 ml of 1 N aqueous sodium hydroxide solution. The resultant solution was stirred at room temperature for 2 hours and then acidified with 1 N aqueous hydrochloric acid solution under cooling with ice. After extracting with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

후처리

  1. customWhite crystals thus formed
  2. washwere washed with ethyl acetate
  3. dissolutiondissolved in 40 ml of 1 N aqueous sodium hydroxide solution
  4. temperatureunder cooling with ice
  5. extractionAfter extracting with ethyl acetate
  6. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c366d52184104f10ba2610b45b3f6d91
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278329B2

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