Sodium Chloride → 7-(3-Bromophenyl)-9-azabicyclo[3.3.1]nonan-3-one

HRID 2061612노트

반응식

HRID 2061612 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:15][CH:14]3[NH:16][CH:10]([CH:11](C(OC)=O)[C:12](=[O:21])[CH:13]3C(OC)=O)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[Na+].[Cl-]>CS(C)=O.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:15][CH:14]3[NH:16][CH:10]([CH2:11][C:12](=[O:21])[CH2:13]3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 5234Sodium ChlorideHCID 70230991Dimethyl 7-(3-bromophenyl)-3-oxo-9-azabicyclo[3.3.1]nonane-2,4-dicarboxylate

생성물 1

HCID 673036667-(3-Bromophenyl)-9-azabicyclo[3.3.1]nonan-3-one

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

Dimethyl 7-(3-bromophenyl)-3-oxo-9-azabicyclo[3.3.1]nonane-2,4-dicarboxylate (89) and NaCl (61.22 g, 1.05 mol) in DMSO (200 ml) and water (10 ml) was placed into a preheated oil bath at 160° C. After stirring for 14 h, the solution was cooled to ambient temperature and exhaustively extracted with EtOAc. The combined organic extracts were dried over MgSO4, filtered, and concentrated to afford compound 90.

후처리

  1. extractionexhaustively extracted with EtOAc
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4b4e305ce1ec41c4b85240dccfa7e403
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283358B2

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