Potassium Carbonate → (S)-ethyl 6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-1-(1-hydroxypropan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

반응식

[OH:1][CH2:2][C@@H:3]([N:5]1[C:14]2[C:9](=[CH:10][C:11](I)=[CH:12][CH:13]=2)[C:8](=[O:16])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6]1)[CH3:4].[CH2:22]([NH:24][C:25]([NH:27][C:28]1[CH:33]=[C:32]([C:34]2[S:35][CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[N:38]=2)[C:31](B2OC(C)(C)C(C)(C)O2)=[CH:30][N:29]=1)=[O:26])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>C(#N)C.O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(P(C(C)(C)C)[C-]1C=CC=C1)(C)(C)C.[C-]1(P(C(C)(C)C)C(C)(C)C)C=CC=C1.[Fe+2]>[CH2:22]([NH:24][C:25](=[O:26])[NH:27][C:28]1[N:29]=[CH:30][C:31]([C:11]2[CH:10]=[C:9]3[C:14](=[CH:13][CH:12]=2)[N:5]([C@@H:3]([CH3:4])[CH2:2][OH:1])[CH:6]=[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:8]3=[O:16])=[C:32]([C:34]2[S:35][CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[N:38]=2)[CH:33]=1)[CH3:23]