Sulfamide → HCID 11492439, 화합물

HRID 2061904노트

반응식

HRID 2061904 반응식
[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH:7]=O.[S:13]([NH2:17])([NH2:16])(=[O:15])=[O:14].[BH4-].[Na+]>C(O)C.O>[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH2:7][NH:16][S:13]([NH2:17])(=[O:15])=[O:14]

참가 물질

6

반응물 3

HCID 82267SulfamideHCID 5944592-Methylbenzofuran-3-carbaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 11492439HCID 11492439, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

2-Methylbenzofuran-3-carbaldehyde (0.51 g, 3.18 mmol) was dissolved in anhydrous ethanol (25 mL). Sulfamide (1.5 g, 16 mmol) was added and the mixture was heated to reflux for 4 days. The mixture was cooled to room temperature. Sodium borohydride (0.132 g, 3.50 mmol) was added and the mixture was stirred at room temperature for 24 hours. The reaction was diluted with water (100 mL) and extracted with DCM (3×75 mL). The extracts were concentrated and suspended in a minimal amount of DCM and filtered to yield the title compound as a white solid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 days
  3. extractionextracted with DCM (3×75 mL)
  4. concentrationThe extracts were concentrated
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-cdfee2381cee4727a5d5804bb3142b73
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283478B2

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