1-Benzothiophene-3-carbaldehyde → HCID 11999023, 화합물

HRID 2061916노트

반응식

HRID 2061916 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([S:13]([NH2:16])(=[O:15])=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:17]1[CH:21]=[C:20]([CH:22]=O)[C:19]2[CH:24]=[CH:25][CH:26]=[CH:27][C:18]1=2.[BH4-].[Na+]>C(O)C>[S:17]1[CH:21]=[C:20]([CH2:22][NH:16][S:13]([N:10]2[CH2:9][CH2:8][CH:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:12][CH2:11]2)(=[O:15])=[O:14])[C:19]2[CH:24]=[CH:25][CH:26]=[CH:27][C:18]1=2

참가 물질

5

반응물 3

HCID 2273281-Benzothiophene-3-carbaldehydeHCID 4311764Sodium borohydrideHCID 119990221-Piperidinesulfonamide, 4-phenyl-

생성물 1

HCID 11999023HCID 11999023, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
45 °C

실험 절차

4-Phenyl-piperidine-1-sulfonic acid amide (1.5 g, 6.24 mmol) was dissolved in ethanol (20 mL). Benzo[b]thiophene-3-carbaldehyde (1.0 g, 6.24 mmol) was then added and the reaction mixture was warmed to 45° C. overnight. The reaction mixture was cooled to room temperature and then treated with sodium borohydride (0.2 g, 5.29 mmol). The reaction was then quenched by addition of 1N HCl. The reaction mixture was stirred overnight. The product precipitated from solution and was removed by vacuum filtration to yield the title compound as a white solid.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe reaction was then quenched by addition of 1N HCl
  3. customThe product precipitated from solution
  4. customwas removed by vacuum filtration

출처 및 근거

ORD 기록
ord-6e44a8b456864583bab24441660ce391
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283478B2

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