Hydrochloric Acid → 4-(8-[1,4]Diazepan-1-yl-6-methyl-quinolin-7-yloxy)-butyric acid methyl ester

HRID 2063575노트

반응식

HRID 2063575 반응식
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[C:16]([O:26][CH2:27][CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])=[C:17]([CH3:25])[CH:18]=[C:19]3[C:24]=2[N:23]=[CH:22][CH:21]=[CH:20]3)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[CH3:33][O:32][C:30](=[O:31])[CH2:29][CH2:28][CH2:27][O:26][C:16]1[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]2)=[C:24]2[C:19]([CH:20]=[CH:21][CH:22]=[N:23]2)=[CH:18][C:17]=1[CH3:25]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 593661754-[7-(3-Methoxycarbonyl-propoxy)-6-methyl-quinolin-8-yl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

생성물 1

HCID 593662074-(8-[1,4]Diazepan-1-yl-6-methyl-quinolin-7-yloxy)-butyric acid methyl ester수율 96%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

The product from step 1 was dissolved in MeOH (18.8 mL) and HCl was added (4M in dioxane, 18.8 mL, 75.2 mmol). The reaction was stirred at room temperature for 2 h, then concentrated. CH2Cl2 was added and this solution was washed with sat. aq. NaHCO3, then brine. The organic was dried over MgSO4, filtered, and concentrated to give the product (1.30 g, 96% yield) as an oil.

후처리

  1. concentrationconcentrated
  2. additionCH2Cl2 was added
  3. washthis solution was washed with sat. aq. NaHCO3
  4. dry with materialThe organic was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3af34e9f423f4ea7b503b30b12d59738
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288373B2

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