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Water → 1,1-Dimethylethyl 4-[(5-methoxy-4-chloro-2-nitrophenyl)amino]-piperidinecarboxylate

HRID 2064152
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HRID 2064152 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5](F)=[CH:4][C:3]=1[O:12][CH3:13].[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]1.O.C(OCC)(=O)C>CN(C)C=O.C(N(C(C)C)CC)(C)C>[CH3:13][O:12][C:3]1[C:2]([Cl:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[C:5]([NH:14][CH:15]2[CH2:16][CH2:17][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:19][CH2:20]2)[CH:4]=1
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참가 물질

7

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 12682914-Amino-1-Boc-piperidineHCID 598501961-Chloro-4-fluoro-2-methoxy-5-nitrobenzene

생성물 1

HCID 598501431,1-Dimethylethyl 4-[(5-methoxy-4-chloro-2-nitrophenyl)amino]-piperidinecarboxylate

시약·촉매·용매 2

HCID 6228
Dimethylformamide
용매
HCID 81531Diisopropylethylamine용매

실험 절차

2-Chloro-4-nitro-5-fluoroanisole (D42) (300 mg) was dissolved in dry dimethylformamide (3 ml) and diisopropylethylamine (0.3 ml), and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (330 mg) were added at room temperature. The mixture was stirred for 3 h, then water and ethyl acetate added. The organic layer was dried over MgSO4, filtered and evaporated, and the residue was crystallised from diethyl ether to afford the title compound, 400 mg.

후처리

  1. dry with materialThe organic layer was dried over MgSO4
  2. filtrationfiltered
  3. customevaporated
  4. customthe residue was crystallised from diethyl ether

출처 및 근거

ORD 기록
ord-8c1e4dff41b747eba27e6bc4dfa2a307
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08288412B2

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